The oxidation in liver of l-tyrosine to acetoacetate through p-hydroxyphenylpyruvate and homogentisic acid
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چکیده
منابع مشابه
The oxidation in liver of l-tyrosine to acetoacetate through p-hydroxyphenylpyruvate and homogentisic acid.
The picture of L-tyrosine metabolism obtained from isotope experiments and other studies on intact animals is still incomplete. Either p-hydroxyphenylpyruvate or 2:5-dihydroxyphenylalanine may be the first intermediate, since either could form the second postulated intermediate, 2:5-dihydroxyphenylpyruvate (Neubauer, 1909), and both are converted to homogentisic acid by alcaptonurics (Neuberger...
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15 صفحه اولInhibition and activation of the oxidation of homogentisic acid.
The biochemical study of homogentisic acid may be said to have begun with the work of Wolkow and Baumann (3), who demonstrated the relation of this compound to the metabolism of tyrosine. The intervening years have seen much effort expended on studies of the pathway of formation of homogentisic acid, but little on its further metabolism beyond the early discovery that it gives rise to ketone bo...
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Homogentisic acid, which is considered to be an intermediate in the metabolism of tyrosine and phenylalanine, is excreted in a number of different conditions. The most widely studied of these, which is caused by a genetic inability to oxidize homogentisic acid, was termed alcaptonuria, owing to the characteristic darkening of the urine on standing. It has also been shown (Sealock & Silberstein,...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1951
ISSN: 0306-3283
DOI: 10.1042/bj0490686